Decrease of serotonin‐S2 receptors in temporal cortex of patients with Parkinson's disease and progressive supranuclear palsy
Identifieur interne : 000313 ( France/Analysis ); précédent : 000312; suivant : 000314Decrease of serotonin‐S2 receptors in temporal cortex of patients with Parkinson's disease and progressive supranuclear palsy
Auteurs : Maloteaux [Belgique] ; E. C. Laterre [Belgique] ; P. M. Laduron [France] ; F. Javoy-Agid [France] ; Yves Agid [France]Source :
- Movement Disorders [ 0885-3185 ] ; 1988.
English descriptors
Abstract
The number of serotonin‐S2 receptors was decreased in the temporal cortex of patients with Parkinson's disease and progressive supranuclear palsy (PSP). There was no significant modification of these receptors in the frontal cortex or in the hippocampus and putamne in both diseases. The decrease in mumber of receptors in PSP was unexpected, because the cerebral cortex is thought to be spared in this disease. There was no correlation between the decrease in number of serotonin‐S2 receptors and the degree of dementia in Parkinson's disease, suggesting that these receptors are not directly involved in the deterioration of cognitive functions.
Url:
DOI: 10.1002/mds.870030310
Affiliations:
- Belgique, France
- Région de Bruxelles-Capitale, Île-de-France
- Bruxelles, Paris
- Hôpital de la Salpêtrière, Université catholique de Louvain
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ISTEX:95B0E59BDA3F0520C6E2F75059829CAC988E38AALe document en format XML
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